Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ENERGY METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ENERGY METABOLISM |
graph TD
ENERGY_METABOLISM["ENERGY METABOLISM"]
ENERGY_METABOLISM -->|"regulates"| Calcium_Homeostasis["Calcium Homeostasis"]
Nad["Nad"] -->|"involved_in"| ENERGY_METABOLISM
AMPK["AMPK"] -->|"regulates"| ENERGY_METABOLISM
NAD_["NAD+"] -->|"involved_in"| ENERGY_METABOLISM
MCT1["MCT1"] -->|"involved_in"| ENERGY_METABOLISM
Mitochondrial_Calcium_Uptake["Mitochondrial Calcium Uptake"] -->|"regulates"| ENERGY_METABOLISM
MITOCHONDRIAL_CALCIUM_UPTAKE["MITOCHONDRIAL CALCIUM UPTAKE"] -->|"regulates"| ENERGY_METABOLISM
m6A_RNA_Methylation["m6A RNA Methylation"] -->|"regulates"| ENERGY_METABOLISM| Target | Relation | Type | Str |
|---|---|---|---|
| Calcium Homeostasis | regulates | process | 0.85 |
| cell death | modulates | process | 0.82 |
| major depressive disorder | associated_with | disease | 0.80 |
| Calcium | modulates | compound | 0.80 |
| NICOTINAMIDE | associated_with | drug | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIA | regulates | cell_type | 0.95 |
| Nad | involved_in | compound | 0.95 |
| MCT1 | involved_in | protein | 0.95 |
| AMPK | regulates | entity | 0.95 |
| AMPK | regulates | protein | 0.92 |
| SIRT1 | regulates | gene | 0.90 |
| Mitochondrial Calcium Uptake | promotes | process | 0.90 |
| AMPK | activates | protein | 0.90 |
| m6A RNA Methylation | regulates | process | 0.90 |
| APOE4 | disrupts | gene | 0.90 |
| GCase | modulates | protein | 0.90 |
| Mitochondrial Calcium Uptake | regulates | process | 0.90 |
| Oleuropein | promotes | compound | 0.90 |
| oleuropein | associated_with | chemical | 0.90 |
| MITOCHONDRIAL CALCIUM UPTAKE | regulates | entity | 0.90 |
| MTOR | regulates | pathway | 0.88 |
| Oleuropein | upregulates | compound | 0.85 |
| Mitochondrial Calcium Uptake | mediates | process | 0.85 |
| NEURON | involved_in | cell_type | 0.85 |
| APOE | regulates | gene | 0.85 |
| Mitophagy Regulation | modulates | process | 0.85 |
| Glutamate Metabolism | associated_with | pathway | 0.85 |
| Glucose Restriction | modulates | process | 0.85 |
| SLC16A7 | involved_in | entity | 0.85 |
| PINK1/PARKIN Signalling | regulates | pathway | 0.85 |
| SLC16A1 | involved_in | entity | 0.85 |
| SLC16A3 | involved_in | entity | 0.85 |
| SLC16A8 | involved_in | entity | 0.85 |
| ATP5A1 | downregulates | gene | 0.83 |
| GLP-1 | enhances | protein | 0.80 |
| AMPK | regulates | gene | 0.80 |
| APOE4 | causes_deficits_in | gene | 0.80 |
| Mtca2+ Uptake | activates | process | 0.80 |
| TREM2 risk variants | inhibits | gene | 0.80 |
| APOE4 | inhibits | gene | 0.80 |
| Drug-Resistant Epilepsy | associated_with | disease | 0.80 |
| OBR | regulates | receptor | 0.75 |
| mitochondrial dysfunction | regulates | process | 0.70 |
| 25673413 | related to | paper | 0.60 |
| AMPK | regulates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ENERGY METABOLISM in their description or question text
No additional research found