gene 1,763 words KG: GADD45B
Contents

GADD45B — Growth Arrest and DNA Damage Inducible Beta

🧬 Gene Info
Gene SymbolGADD45B
Full NameGrowth Arrest and DNA Damage Inducible Beta
AliasesGrowth Arrest and DNA Damage 45 Beta
Chromosome19p13.3
FunctionGADD45B participates in several critical cellular processes
Molecular Weight18 kDa
Amino Acids165 aa
PathwaysMAPK, NF-κB, NF-κB signaling, MAPK pathway
UniProt IDQ9ULLI
NCBI Gene ID10988
Ensembl IDENSG00000099899
OMIM604411
GeneCardsGADD45B
Human Protein AtlasGADD45B
Associated Diseasesneurodegeneration
InteractionsCDKN1A, FERROPTOSIS, GADD45A, GADD45G, MET, PPP3CC
KG Connections26 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
PARP1 Inhibition Therapy
Score: 0.74
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (15)

CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: inhibits
necroptosis
general · KG edge: associated_with
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
MET - MET Proto-Oncogene, Receptor Tyrosine Kinase
gene · KG edge: activates

Knowledge Graph (12 edges)

GADD45A activates GADD45B
GADD45B activates GADD45G
GADD45B activates MET
GADD45A regulates GADD45B
GADD45B regulates GADD45G
SOD2 activates GADD45B
GADD45B activates CDKN1A
GADD45B activates PPP3CC
GADD45B activates Ms
GADD45B activates Depression

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