| Gene Symbol | EFNA1 |
| Full Name | Ephrin A1 |
| Chromosome | 1q21.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | adult tissues, with high expression in the brain, particularly in the hippocampus, cortex, and |
| Molecular Weight | 25 kDa |
| Amino Acids | 205 aa |
| UniProt ID | P20827 |
| Ensembl ID | ENSG00000139842 |
| GeneCards | EFNA1 |
| Human Protein Atlas | EFNA1 |
| RAS/MAPK pathway | EPHA activation recruits GRB2/SOS complexes, activating RAS-RAF-MEK-ERK signaling important for neuronal differentiation and plasticity |
| PI3K/AKT pathway | Phosphatidylinositol 3-kinase signaling promotes cell survival and regulates synaptic plasticity |
| Rho GTPase pathways | EPHA signaling modulates RAC, CDC42, and RHOA activities to control cytoskeletal dynamics and dendritic spine morphology |
| STAT pathways | EPHA receptors can activate STAT transcription factors, modulating gene expression programs |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, cancer |
| Databases | GeneCardsNCBI GeneHPASTRING |
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