gene 1,801 words KG: CSPG4
Contents

CSPG4

🧬 Gene Info
Gene SymbolCSPG4
Full NameChondroitin Sulfate Proteoglycan 4
AliasesCSPG4 (NG2)
Chromosome15q24.2
Protein TypeReceptor
Functionencodes a large cell surface proteoglycan that is primarily expressed on pericytes and mesenchymal progenitor cells [1](https://pubmed.
Molecular Weight400 kDa
Amino Acids224 aa
Exons33
UniProt ID[Q6UVK1](https://www.uniprot.org/uniprot/Q6UVK1)
Ensembl IDENSG00000173546
GeneCardsCSPG4
Human Protein AtlasCSPG4
N-terminal Signal PeptideDirects cotranslational translocation to the ER
Associated DiseasesALS
InteractionsBRAIN INJURY, HSPG2, INFLAMMATION, NOTCH, PROGRANULIN, Proteins
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Glial Glycocalyx Remodeling Therapy
Score: 0.65
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71

Related Analyses (3)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Traumatic Brain Injury and Alzheimer's Disease Relationship
validation · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40

See Also (10)

Progranulin (PGRN) - Biomarker
biomarker · KG edge: associated_with
Astrocytes
cell · KG edge: regulates
blarcamesine-axon
clinical_trial · KG edge: regulates
NeuRon Therapeutics
company · KG edge: expressed_in
Notch and Gamma-Secretase Modulators for Parkinson's Di
company · KG edge: interacts_with

Knowledge Graph (12 edges)

PROGRANULIN interacts_with CSPG4
CSPG4 interacts_with HSPG2
CSPG4 associated_with PROGRANULIN
CSPG4 interacts_with PROGRANULIN
CSPG4 binds_to HSPG2
INFLAMMATION interacts_with CSPG4
BRAIN INJURY interacts_with CSPG4
CSPG4 regulates AXON
CSPG4 regulates AND
CSPG4 regulates ASTROCYTES

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