gene

CSNK1E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK1E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

1Analyses

5Outgoing

3Incoming

0Experiments

1Debates

Summary

Page for CSNK1E - Casein Kinase 1 Epsilon

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🧬 Gene Info

Gene Symbol	CSNK1E
Full Name	Casein Kinase 1 Epsilon
Aliases	Page for CSNK1E
Chromosome	15q21.2
Protein Type	Kinase
Function	CSNK1E encodes casein kinase 1 epsilon (CK1ε), a serine/threonine protein kinase that plays essential roles in circadian rhythm regulation, Wnt signaling, DNA repair), and various neuronal signaling p
Subcellular Localization	s and functions
Molecular Weight	55 kDa
Amino Acids	409 aa
Pathways	Wnt signaling, wnt
UniProt ID	P49674
NCBI Gene ID	1454
Ensembl ID	ENSG00000101391
OMIM	604066
GeneCards	CSNK1E
Human Protein Atlas	CSNK1E
Associated Diseases	neurodegeneration
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, CSNK1D, MOTOR NEURONS
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CSNK1E — AlphaFold P49674 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CSNK1E - Casein Kinase 1 Epsilon

gene · 1140 words

→

CSNK1E Protein

protein · 777 words

→

Pathway Diagram

graph TD
    CSNK1E["CSNK1E"]
    Als{"Als"}
    CSNK1E -->|"inhibits"| Als
    Ms{"Ms"}
    CSNK1E -->|"inhibits"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    CSNK1E -->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    ALS["ALS"]
    CSNK1E -->|"inhibits"| ALS
    neurodegeneration["neurodegeneration"]
    CSNK1E -->|"implicated in"| neurodegeneration
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"inhibits"| CSNK1E
    CSNK1D["CSNK1D"]
    CSNK1D -->|"inhibits"| CSNK1E
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"inhibits"| CSNK1E
    style CSNK1E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
circadian_clock_entrainment	modulates	mechanism	0.70
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
ALS	inhibits	gene	0.60

Incoming (3)

Source	Relation	Type	Str
CSNK1D	inhibits	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning CSNK1E in their description or question text

No additional research found