gene

PTCH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTCH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

15Outgoing

5Incoming

0Experiments

0Debates

Summary

PTCH1 encodes the principal receptor for Hedgehog signaling, which plays crucial roles in neuronal development, dopaminergic function, and is implicated in Parkinson's disease pathogenesis.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PTCH1
Full Name	Patched 1 (Hedgehog Receptor)
Chromosome	9q22.32
Function	is a 12-pass transmembrane protein that functions as the negative regulator of the Hedgehog pathway by inhibiting Smoothened (SMO) in the absence of Hedgehog ligands[@gates2015].
Primary Expression	several regions relevant to neurodegenerative disease[@khalil2019]:
Molecular Weight	160 kDa
Amino Acids	1448 aa
Exons	24
Pathways	signaling: Canonical Pathway:
GeneCards	PTCH1
Human Protein Atlas	PTCH1
Twelve transmembrane domains	Organized in two clusters of six helices each, forming the protein's transmembrane architecture
Sterol-sensing domain (SSD)	A conserved region in transmembrane helices 6-10 that mediates interaction with SMO and responds to cholesterol derivatives
Large extracellular loops	Multiple loops facing the extracellular space that bind Hedgehog ligands (SHH, IHH, DHH)
Intracellular C-terminal tail	Cytoplasmic domain involved in downstream signaling regulation
Associated Diseases	Parkinson's disease, Alzheimer's disease
Interactions	APOPTOSIS, ATXN3, INFLAMMATION, NEURON, SHH, SYNAPSE
KG Connections	20 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PTCH1 — Patched 1 (Hedgehog Receptor)

gene · 1747 words

→

Pathway Diagram

graph TD
    PTCH1["PTCH1"]
    CSNK1D["CSNK1D"]
    CSNK1D -->|"regulates"| PTCH1
    Als{"Als"}
    PTCH1 -->|"activates"| Als
    Inflammation{"Inflammation"}
    PTCH1 -->|"activates"| Inflammation
    SHH["SHH"]
    PTCH1 -->|"expressed_in"| SHH
    ASTROCYTES["ASTROCYTES"]
    PTCH1 -->|"expressed_in"| ASTROCYTES
    GENES["GENES"]
    PTCH1 -->|"expressed_in"| GENES
    ASTROCYTE["ASTROCYTE"]
    PTCH1 -->|"expressed_in"| ASTROCYTE
    NEURON["NEURON"]
    PTCH1 -->|"activates"| NEURON
    SYNAPSE["SYNAPSE"]
    PTCH1 -->|"activates"| SYNAPSE
    Hedgehog(["Hedgehog"])
    PTCH1 -->|"activates"| Hedgehog
    Sonic_Hedgehog(["Sonic Hedgehog"])
    PTCH1 -->|"activates"| Sonic_Hedgehog
    Apoptosis(["Apoptosis"])
    PTCH1 -->|"activates"| Apoptosis
    Chaperone(["Chaperone"])
    PTCH1 -->|"activates"| Chaperone
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    PTCH1 -->|"activates"| Unfolded_Protein_Response
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| PTCH1

Outgoing (15)

Target	Relation	Type	Str
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Chaperone	activates	pathway	0.60
Unfolded Protein Response	activates	pathway	0.60
SHH	expressed_in	gene	0.60
Sonic Hedgehog	activates	pathway	0.60
SHH	inhibits	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
NEURON	activates	gene	0.60
SYNAPSE	activates	gene	0.60
Hedgehog	activates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
CSNK1D	regulates	gene	0.80
ATXN3	inhibits	gene	0.60
ATXN3	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTCH1 in their description or question text

No additional research found