| Gene Symbol | CDK5R2 |
| Full Name | Cyclin-Dependent Kinase 5 Regulatory Subunit 2 |
| Chromosome | 9q22.33 |
| Function | is a neuron-specific gene that encodes a regulatory subunit of CDK5, a proline-directed serine/threonine kinase critical for neuronal function. |
| Primary Expression | Neuron-specific |
| Subcellular Localization | ## Disease Associations |
| Molecular Weight | 36 kDa |
| UniProt ID | Q16569 |
| NCBI Gene ID | 8941 |
| Ensembl ID | ENSG00000100157 |
| GeneCards | CDK5R2 |
| Human Protein Atlas | CDK5R2 |
| Neuron-specific activation | p39 expression is largely restricted to neurons, making CDK5 activity in the brain uniquely regulated by this activator |
| Alternative splicing | The CDK5R2 gene produces multiple isoforms with different tissue distributions and regulatory properties |
| Calcium-dependent activation | p39 cleavage by calpain produces p25, a hyperactive fragment similar to p35 cleavage in disease states |
| Associated Diseases | Inflammation |
| Interactions | FGF13, GRM5, ISG15, SCN2B, SCN8A, SLC17A7 |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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