Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BTRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Beta-Transducin Repeat Containing Protein - F-box ubiquitin ligase subunit involved in protein degradation and neurodegeneration
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| Gene Symbol | BTRC |
| Full Name | Beta-Transducin Repeat Containing Protein |
| Chromosome | 10q24.32 |
| Protein Type | Ligase |
| Function | is a critical regulator of numerous cellular processes, including cell cycle progression, DNA damage responses, circadian rhythm, inflammatory signaling, and protein quality control. |
| Amino Acids | 542 aa |
| Pathways | Autophagy, Inflammasome, Mitophagy, Nlrp3 Inflammasome |
| UniProt ID | [Q9Y297](https://www.uniprot.org/uniprot/Q9Y297) |
| Ensembl ID | ENSG00000166167 |
| GeneCards | BTRC |
| Human Protein Atlas | BTRC |
| Recognition motif | DSGxxS or DSxGxxS (where x is any amino acid) |
| Phosphorylation requirement | Both serine residues must be phosphorylated |
| Dimerization requirement | β-TrCP functions as a dimer |
| NF-κB pathway | IκBα, IκBβ, NF-κB2/p100, HBV X protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | AUTOPHAGY, CANCER, CYTOKINES, MITOCHONDRIA, MITOPHAGY, NLRP3 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BTRC["BTRC"]
Als{"Als"}
BTRC -->|"activates"| Als
Cancer{"Cancer"}
BTRC -->|"activates"| Cancer
CANCER["CANCER"]
BTRC -->|"activates"| CANCER
ERK1["ERK1"]
BTRC -->|"associated with"| ERK1
AUTOPHAGY["AUTOPHAGY"]
BTRC -->|"activates"| AUTOPHAGY
ERK2["ERK2"]
BTRC -->|"associated with"| ERK2
Autophagy(["Autophagy"])
BTRC -->|"activates"| Autophagy
Proteasome(["Proteasome"])
BTRC -->|"associated with"| Proteasome
Inflammasome(["Inflammasome"])
BTRC -->|"activates"| Inflammasome
Mitophagy(["Mitophagy"])
BTRC -->|"activates"| Mitophagy
Mapk(["Mapk"])
BTRC -->|"associated with"| Mapk
neurodegeneration["neurodegeneration"]
BTRC -->|"implicated in"| neurodegeneration
MAPK3["MAPK3"]
MAPK3 -->|"associated with"| BTRC
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"activates"| BTRC
MAPK1["MAPK1"]
MAPK1 -->|"associated with"| BTRC
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"activates"| BTRC
NLRP3["NLRP3"]
NLRP3 -->|"activates"| BTRC
ULK1["ULK1"]
ULK1 -->|"associated with"| BTRC
style BTRC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Autophagy | activates | pathway | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ERK1 | associated_with | gene | 0.60 |
| ERK2 | associated_with | gene | 0.60 |
| Nlrp3 Inflammasome | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BTRC in their description or question text
No additional research found