| Gene Symbol | VCP |
| Full Name | Targeted Therapy |
| Chromosome | 9p13.3 |
| Protein Family | AAA+ ATPase family |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule inhibitors of VCP ATPase activity affecting protein quality control |
| Mechanism of Action | Small molecule inhibitors of VCP ATPase activity affecting protein quality control |
| Primary Expression | Ubiquitous - Brain, Muscle, Spinal cord |
| Subcellular Localization | Cytoplasm, nucleus, ER, mitochondria |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase I |
| Molecular Weight | 97 kDa |
| Amino Acids | 806 aa |
| Exons | 17 |
| Pathways | Akt, Autophagy, Er Stress, Mitophagy, Ubiquitin-Proteasome |
| UniProt ID | P55072 |
| Ensembl ID | ENSG00000165280 |
| GeneCards | VCP |
| Human Protein Atlas | VCP |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, AMI, amyotrophic lateral sclerosis |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | Actin, AD, AKT, ALPHA-SYNUCLEIN, ALS, ALS-CAUSING MUTATIONS |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | VCP-Mediated Autophagy Enhancement VCP/p97 ATPase mutations impair extraction of ubiq VCP-Mediated Autophagy Enhancement |
| KG Connections | 990 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!