concept

SMD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

23Outgoing

6Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SMD1
Key Genes/Proteins	Actin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, CHMP7, MOTOR NEURONS, NEURON
Related Diseases	Aging, Als, Amyotrophic Lateral Sclerosis

Pathway Diagram

graph TD
    SMD1["SMD1"]
    SMD1 -->|"regulates"| CHMP7["CHMP7"]
    SMD1 -->|"regulates"| STMN2_Splicing["STMN2 Splicing"]
    SMD1 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMD1 -->|"expressed in"| Als["Als"]
    SMD1 -->|"interacts"| Aging["Aging"]
    SMD1 -->|"expressed in"| ALS["ALS"]
    SMD1 -->|"interacts"| TDP_43["TDP-43"]
    SMD1 -->|"expressed in"| STMN2["STMN2"]
    STMN2 -->|"expressed in"| SMD1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| SMD1
    TDP_43 -->|"interacts"| SMD1
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"activates"| SMD1
    SMN["SMN"] -->|"interacts"| SMD1
    NEURON["NEURON"] -->|"interacts"| SMD1

Outgoing (23)

Target	Relation	Type	Str
CHMP7	regulates	protein	0.92
STMN2 Splicing	regulates	process	0.88
Aging	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
RNA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
CHMP7	interacts_with	gene	0.60
Stem Cell	activates	cell_type	0.60
ALS	expressed_in	gene	0.60
Neuron	interacts_with	cell_type	0.60
TDP-43	interacts_with	gene	0.60
STMN2	expressed_in	gene	0.60
SMN	interacts_with	gene	0.60
Tdp-43	interacts_with	pathway	0.60
Actin	interacts_with	protein	0.60
Raf	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RNA SPLICING	interacts_with	gene	0.60
MOTOR NEURONS	activates	gene	0.60
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
STMN2	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
TDP-43	interacts_with	gene	0.60
MOTOR NEURONS	activates	gene	0.60
SMN	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMD1 in their description or question text

No additional research found