concept

SIK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

21Outgoing

8Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SIK1
Key Genes/Proteins	CANCER, FERROPTOSIS, HDAC5, Raf, SLC7A11, STAT6
Related Diseases	Cancer, Carcinoma, ferroptosis, Ferroptosis Resistance, Pancreatic Ductal Adenocarcinoma
Related Pathways	Ferroptosis

Pathway Diagram

graph TD
    SIK1["SIK1"]
    SIK1 -->|"phosphorylates"| HDAC5["HDAC5"]
    SIK1 -.biomarker for.-> Pancreatic_Ductal_Adenocarcino["Pancreatic Ductal Adenocarcinoma"]
    SIK1 -->|"correlates_with"| SLC7A11["SLC7A11"]
    SIK1 -->|"inhibits"| ferroptosis["ferroptosis"]
    SIK1 -->|"activates"| Tumor["Tumor"]
    SIK1 -->|"activates"| Cancer["Cancer"]
    SIK1 -->|"activates"| Carcinoma["Carcinoma"]
    YKL_05_099["YKL-05-099"] -->|"inhibits"| SIK1
    HDAC5 -->|"activates"| SIK1
    SLC7A11 -->|"activates"| SIK1
    STAT6["STAT6"] -->|"activates"| SIK1
    CANCER["CANCER"] -->|"activates"| SIK1
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| SIK1

Outgoing (21)

Target	Relation	Type	Str
HDAC5	phosphorylates	gene	0.95
Ferroptosis Resistance	associated_with	phenotype	0.95
ferroptosis resistance	promotes	process	0.90
Pancreatic Ductal Adenocarcinoma	biomarker_for	disease	0.85
SLC7A11	correlates_with	gene	0.85
ferroptosis	inhibits	phenotype	0.72
HDAC5	activates	protein	0.72
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
FERROPTOSIS	activates	gene	0.60
TRIM28	activates	gene	0.60
CANCER	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Raf	activates	protein	0.60
ferroptosis	participates_in	pathway	0.60
SLC7A11	interacts_with	gene	0.60
SLC7A11	activates	gene	0.60
STAT6	activates	gene	0.60
ferroptosis	regulates	process	0.60
ferroptosis	activates	process	0.60

Incoming (8)

Source	Relation	Type	Str
YKL-05-099	inhibits	drug	0.90
HDAC5	associated_with	gene	0.60
HDAC5	activates	gene	0.60
SLC7A11	activates	gene	0.60
STAT6	activates	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
HDAC5	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIK1 in their description or question text

No additional research found