| Gene Symbol | UBIQUITIN |
| Aliases | UBIQUITINPROTEIN |
| Function | is a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates. |
| Subcellular Localization | </th><td>Cytoplasm, Nucleus, Mitochondria, Membrane</td></tr> |
| Pathways | Adaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy |
| GeneCards | UBIQUITIN |
| Human Protein Atlas | UBIQUITIN |
| Amino acids | 76 |
| Molecular weight | 8,467 Da |
| Sequence | Highly conserved across eukaryoths |
| C-terminal Gly76 | Required for isopeptide bond formation |
| PDB | 1UBQ (first solved by X-ray crystallography) |
| Fold type | β-grasp (β-grasp fold) |
| Secondary structure | Five β-strands (β1-β5), one α-helix |
| Stability | Exceptional—requires 6M guanidine HCl to denature |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | proteolysis-targeting chimeras, RAPAMYCIN |
| Interactions | ABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1 |
| KG Connections | 3814 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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