| Gene Symbol | TARDBP |
| Aliases | TARDBPPROTEIN |
| Chromosome | 1p36 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | RNA-binding and transcription regulation, challenging for small molecule targeting |
| Mechanism of Action | RNA-binding and transcription regulation, challenging for small molecule targeting |
| Subcellular Localization | **Acetylation**: At K263, K331, affects RNA binding |
| Druggability | Low (0.43) |
| Clinical Stage | Phase III |
| Molecular Weight | 43 kDa |
| Amino Acids | 4477 aa |
| Pathways | Apoptosis, Autophagy, Immune Response, Oxidative Stress, Tdp-43 |
| UniProt ID | A0A087WYY0 |
| GeneCards | TARDBP |
| Human Protein Atlas | TARDBP |
| Associated Diseases | AD, ALI, Als, ALS-FTD, Alzheimer |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN, Transcribed Rnas |
| Interactions | ABCA1, AD, AIF1, ALS, ALS-CAUSING MUTATIONS, AMPK |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | STMN2 Cryptic Exon Inclusion is the Earliest Loss- Cross-Seeding Prevention Strategy Glial Neuroinflammatory Amplification by TDP-43 Pa (+7 more) |
| KG Connections | 1210 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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