Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALS-FTD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TARDBP | associated_with | protein | 0.95 |
| TDP-43 | associated_with | protein | 0.95 |
| Loss Of TDP-43 Splicing Repression | associated_with | mechanism | 0.95 |
| Cryptic HDGFL2 | biomarker_for | biomarker | 0.93 |
| C9ORF72 | risk_factor_for | gene | 0.92 |
| Cytoplasmic TDP-43 Aggregation | causes | mechanism | 0.90 |
| Impaired Cryptic Exon Repression | biomarker_for | biomarker | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Stathmin-2 Splice Switching to Prevent Axonal Degeneration A | 0.664 | neurodegeneration | RNA binding protein dysregulation across |
| Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat | 0.620 | neurodegeneration | Gap 006 analysis (archived stub) |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ALS-FTD in their description or question text
No additional research found