| Gene Symbol | SIRT1 |
| Aliases | SIRT1PROTEIN |
| Chromosome | 10q21.3<br> |
| Target Class | Epigenetic Regulator |
| Function | SIRT1 uses NAD+ as a cofactor, linking its activity to cellular energy status and metabolic health. |
| Mechanism of Action | SIRT1 activation via NAD+ precursors or allosteric activators deacetylates tau (reducing aggregation), enhances mitophagy, and restores circadian gene expression |
| Subcellular Localization | </strong></td><td>Nucleus, Cytoplasm (shuttles between compartments)</td></tr> |
| Druggability | Medium (0.48) |
| Clinical Stage | Phase III |
| Pathways | Akt, Ampk Signaling, Angiogenesis, Apoptosis, Autophagy |
| UniProt ID | Q96EB6 |
| NCBI Gene ID | 23411 |
| Ensembl ID | ENSG00000096717 |
| GeneCards | SIRT1 |
| Human Protein Atlas | SIRT1 |
| Associated Diseases | aging, aging-related diseases, Als, Alzheimer |
| Known Drugs/Compounds | curcumin, DSS, EDARAVONE, Ginsenoside Re, intermittent fasting, kaempferol |
| Interactions | ABCA1, ACAT1, ACETYL-COA, ACHE, ACOX1, ACTB |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | SIRT1-Mediated Reversal of TREM2-Dependent Microgl Nutrient-Sensing Epigenetic Circuit Reactivation NRF2-Mediated Metabolic Reprogramming: HBOT as Dir (+3 more) |
| KG Connections | 3094 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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