| Gene Symbol | RANPROTEIN |
| Full Name | RAN GTPase |
| Protein Family | Ras superfamily, Rab subfamily |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 24 kDa |
| Amino Acids | 216 amino acids |
| UniProt ID | P62834 |
| GeneCards | RANPROTEIN |
| Human Protein Atlas | RANPROTEIN |
| Nuclear localization signal | Although primarily nuclear, RAN contains motifs for nuclear import[@cook2007] |
| Importin-β shuttling | RAN-GTP regulates the binding and release of importin-β and importin-α, controlling protein import into the nucleus[@gorlich1996] |
| Nuclear-cytoplasmic gradient | The RAN-GTP gradient across the nuclear envelope is essential for directional transport |
| Protein and RNA export | RAN regulates the export of proteins, mRNA, and other cargo through the nuclear pore complex (NPC)[@tran2006] |
| CRM1/exportin pathway | RAN-GTP regulates the CRM1-mediated export pathway |
| Associated Diseases | Aging, Als, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, frontotemporal dementia |
| Known Drugs/Compounds | metformin, rapamycin |
| Interactions | Actin, Akt, AKT, ALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS |
| KG Connections | 154 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!