protein 506 words KG: PLCG1
Contents

Phospholipase C Gamma 1 Protein

🔬 Protein Info
Gene SymbolPLCG1
AliasesPage for PLCG1
Protein FamilyPhospholipase C gamma family
Protein TypeEnzyme
FunctionPLCG1 is a phospholipase C isoform activated by receptor tyrosine kinases (RTKs).
Molecular Weight148.5 kDa
Amino Acids1290 aa
Pathwaysoncogenic pathway activation
UniProt IDP19174
GeneCardsPLCG1
Human Protein AtlasPLCG1
Associated Diseasesneurodegeneration
InteractionsAUTOPHAGY, EGFR, LAMP2A, RB1, TP53
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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Related Hypotheses (4)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
CREBBP Gene
gene · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

RB1 activates PLCG1
EGFR activates PLCG1
EP300 therapeutic_target PLCG1
TP53 activates PLCG1
GBM therapeutic_target PLCG1
CREBBP therapeutic_target PLCG1
PLCG1 activates oncogenic pathway activation
PLCG1 activates LAMP2A
NRAS co_expressed_with PLCG1
PLCG1 co_expressed_with TET2

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