| Gene Symbol | PERKPROTEIN |
| Full Name | perk-protein |
| Chromosome | 2p22.2 |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | to the ER membrane that activates the Integrated Stress Response (ISR) when misf |
| Exons | 18 |
| UniProt ID | Search UniProt |
| GeneCards | PERKPROTEIN |
| Human Protein Atlas | PERKPROTEIN |
| eIF2α phosphorylation site | PERK phosphorylates eIF2α at Ser^51 to attenuate global translation |
| PERK | Activated by ER stress (misfolded proteins, calcium depletion, hypoxia) |
| GCN2 | Activated by amino acid deprivation |
| PKR | Activated by viral infection |
| HRI | Activated by heme deficiency |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Dolutegravir, DTG, rapamycin, SB202190 |
| Interactions | ABCA1, ABCA7, ABCD3, ACETYL-COA, ADSL, AGGF1 |
| KG Connections | 878 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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