| Gene Symbol | NAMPT |
| Full Name | Nicotinamide Phosphoribosyltransferase |
| Aliases | Nicotinamide Phosphoribosyltransferase/Visfatin |
| Chromosome | 7q22.3 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule competitive inhibitors of NAD+ biosynthesis enzyme |
| Mechanism of Action | Small molecule competitive inhibitors of NAD+ biosynthesis enzyme |
| Druggability | Low (0.45) |
| Clinical Stage | Phase II |
| Molecular Weight | 52 kDa |
| Pathways | Akt, Angiogenesis, Autophagy, Cerebrovascular, Cholesterol Metabolism |
| UniProt ID | A0A7P0TA73 |
| NCBI Gene ID | 10135 |
| Ensembl ID | ENSG00000105835 |
| OMIM | 608064 |
| GeneCards | NAMPT |
| Human Protein Atlas | NAMPT |
| Associated Diseases | aging, Als, Alzheimer |
| Known Drugs/Compounds | NAMPT positive allosteric modulators, nicotinamide |
| Interactions | Actin, AGING, AKT, AMPK, AND, APOE4 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | TREM2 R47H Variant-Driven Metabolic Dysfunction as Metabolic NAD+ Salvage Pathway Enhancement Through NAD+ Salvage Pathway Optimization |
| KG Connections | 575 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!