| Gene Symbol | INS |
| Aliases | Insulin |
| Chromosome | 11p15.5 |
| Subcellular Localization | </b></td><td>Secreted, cytoplasm</td></tr> |
| Molecular Weight | 6 kDa |
| Amino Acids | 110 aa |
| Pathways | PI3K, MAPK |
| GeneCards | INS |
| Human Protein Atlas | INS |
| PI3K/Akt pathway | Promotes neuronal survival, protein synthesis, and glycogen metabolism |
| MAPK/ERK pathway | Regulates cell growth, differentiation, and synaptic plasticity |
| IRS proteins | Key adaptors linking IR to downstream effectors |
| LTP induction | Insulin facilitates long-term potentiation in hippocampal neurons |
| AMPA receptor trafficking | Insulin regulates AMPA receptor insertion into synaptic membranes |
| Dendritic spine morphology | Insulin influences spine density and morphology |
| Associated Diseases | Als, Alzheimer, Cancer, Obesity, Parkinson |
| Known Drugs/Compounds | metformin |
| Interactions | AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK |
| KG Connections | 398 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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