| Gene Symbol | GRP78 |
| Full Name | Glucose-Regulated Protein 78 |
| Function | In neurodegenerative diseases, BiP serves as both a sensor of ER stress and a protective factor against protein aggregation. |
| Subcellular Localization | </td><td>Endoplasmic reticulum lumen (resident)</td></tr> |
| Molecular Weight | 78 kDa |
| Pathways | OXIDATIVE PHOSPHORYLATION, Microrna, Chaperone |
| GeneCards | GRP78 |
| Human Protein Atlas | GRP78 |
| C-terminal KDEL sequence | ER retention signal (KDEL in humans: HDEL) |
| Signal peptide | N-terminal signal sequence for ER targeting |
| Nascent protein binding | Binds newly synthesized proteins entering the ER |
| Folding assistance | Accelerates proper folding |
| Quality control | Retains misfolded proteins for degradation |
| Assembly | Facilitates multi-subunit complex formation |
| Calcium binding | Acts as calcium buffer in ER lumen |
| Associated Diseases | ALS, multiple sclerosis |
| Interactions | DDIT3, DEPTOR, EGFR, EIF2A, EIF2AK3, ENDOPHILIN |
| KG Connections | 84 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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