| Gene Symbol | CLOCK |
| Full Name | Circadian Locomotor Output Cycles Kaput |
| Chromosome | 4q12 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | CLOCK is a bHLH-PAS transcription factor that functions as the master regulator of the circadian clock. |
| Mechanism of Action | Modulation of circadian transcriptional activity through protein-protein interaction disruption |
| Subcellular Localization | </strong></td><td>Nucleus (primary)</td></tr> |
| Druggability | Low (0.35) |
| Clinical Stage | Approved |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, CIRCADIAN_RHYTHM |
| UniProt ID | O15516 |
| NCBI Gene ID | 9609 |
| Ensembl ID | ENSG00000132266 |
| OMIM | 601851 |
| GeneCards | CLOCK |
| Human Protein Atlas | CLOCK |
| Associated Diseases | aging, Als, Alzheimer |
| Known Drugs/Compounds | nicotinamide |
| Interactions | ACETYL-COA, Actin, AGING, AHR, AKT, ALOX12 |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Circadian Clock-Autophagy Synchronization Temporal Decoupling via Circadian Clock Reset |
| KG Connections | 1348 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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