Contents

CHMP2B Protein

🔬 Protein Info

Gene Symbol	CHMP2B
Aliases	Charged Multivesicular Body Protein 2B
Chromosome	3p11.2
Protein Family	ESCRT-III complex family
Protein Type	Other
Target Class	Other
Function	Under physiological conditions, CHMP2B performs essential functions in the nervous system.
Mechanism of Action	Therapeutic agents targeting CHMP2B would modulate ESCRT-III complex function to enhance endosomal sorting and autophagy, potentially clearing protein aggregates associated with frontotemporal dementia or compensating for loss-of-function mutations. Strategies include antisense oligonucleotides to modulate protein expression, autophagy enhancers to promote cellular clearance pathways, or small molecules that stabilize ESCRT-III complex assembly and function.
Primary Expression	Endosomes and endolysosomal membranes
Subcellular Localization	</th><td>Endosomal membrane, multivesicular body, nucleus</td></tr>
Druggability	Low (0.32)
Clinical Stage	Phase II
Molecular Weight	24 kDa
Amino Acids	213 aa
Pathways	Lysosomal function / degradation
UniProt ID	Q9UQN3
GeneCards	CHMP2B
Human Protein Atlas	CHMP2B
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, dementia
Known Drugs/Compounds	rapamycin
Interactions	Actin, ALS, ALS-CAUSING MUTATIONS, ALZHEIMER, AND, App
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Lysosomal Membrane Repair Enhancement
KG Connections	438 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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