Contents

CDKN2A Protein

🔬 Protein Info

Gene Symbol	CDKN2A
Aliases	CDKN2APROTEIN
Chromosome	9p21.3
Function	is a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight	16 kDa
Amino Acids	156 aa
Pathways	Glycolysis, Tgf-Β
UniProt ID	P42771
NCBI Gene ID	1029
Ensembl ID	ENSG00000147883
GeneCards	CDKN2A
Human Protein Atlas	CDKN2A
p16INK4a promoter	Controls expression of the p16INK4a protein through exon 1α and the combined exons 2 and 3.
p14ARF promoter	Controls expression of the p14ARF protein through exon 1β, which is located 5 kb upstream of the p16INK4a exon 1α, combined with exons 2 and 3 but in an alternative reading frame.
Ankyrin Repeats (residues 34-139)	Five ankyrin repeats form the core structural element of the protein, creating a curved, arm-like structure that mediates protein-protein interactions.
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	AGING, AKT, AKT3, AND, APC, APOPTOSIS
SciDEX Hypotheses	Hippocampal-Cortical Transcriptomic Divergence Rev Senescence-Tau Decoupling Therapy
KG Connections	457 knowledge graph edges
Databases	GeneCards HPA STRING

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