protein 643 words KG: C1QAPROTEIN
Contents

C1qA Protein

🔬 Protein Info
Gene SymbolC1QAPROTEIN
Full NameC1qA
Protein TypeProtein
Target ClassSignaling Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Mechanism of ActionComplement cascade inhibitor or antibody-mediated neutralization
DruggabilityLow (0.41)
Clinical StagePhase II
UniProt IDSearch UniProt
GeneCardsC1QAPROTEIN
Human Protein AtlasC1QAPROTEIN
Associated DiseasesA1_astrocytes, AD, Aging, ALI, Als
Known Drugs/CompoundsC1q_mimetic_decoys
InteractionsAIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
SciDEX TargetView Target Profile (7 clinical trials)
SciDEX HypothesesComplement C1q Mimetic Decoy Therapy
Complement C1QA Spatial Gradient in Cortical Layer
Complement C1q Subtype Switching (+5 more)
KG Connections701 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (12)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (8)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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