| Gene Symbol | BDNF |
| Full Name | Brain-Derived Neurotrophic Factor |
| Chromosome | 11p14.1 |
| Protein Family | Neurotrophin family |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | Protein replacement therapy or small molecule mimetic |
| Mechanism of Action | Protein replacement therapy or small molecule mimetic |
| Primary Expression | Secreted, Synaptic vesicles |
| Druggability | Low (0.29) |
| Clinical Stage | Phase II |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol |
| UniProt ID | P23560 |
| NCBI Gene ID | 627 |
| Ensembl ID | ENSG00000176697 |
| OMIM | 113505 |
| GeneCards | BDNF |
| Human Protein Atlas | BDNF |
| Associated Diseases | Addiction, ADHD, aging, allergic airway inflammation, Als |
| Known Drugs/Compounds | acupuncture, aducanumab, ANTIDEPRESSANTS, BAICALEIN, Bifidobacterium bifidum CCFM1163, Bnt162B2 |
| Interactions | A2A receptor, A2A Receptor, ABCA7, ABETA, ACC, ACE |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Hippocampal CA3-CA1 synaptic rescue via DHHC2-medi Hippocampal CA3-CA1 circuit rescue via neurogenesi BDNF-mediated hippocampal synaptic rescue as a mod (+2 more) |
| KG Connections | 4726 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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