protein 879 words KG: ALSIN
Contents

Alsin Protein (ALS2)

🔬 Protein Info
Gene SymbolALSIN
Full NameAlsin (ALSIN)
AliasesALS2/Alsin
Chromosome2q33.
Protein TypeGene
FunctionAlsin is a multiunctional protein with several key cellular roles:
Subcellular Localization</strong></td><td>Endosomes, Cytoplasm</td></tr>
Molecular Weight210 kDa
Amino Acids847 aa
GeneCardsALSIN
Human Protein AtlasALSIN
Rab5 activationPromotes early endosome fusion and trafficking
Rac1 activationRegulates actin cytoskeleton and membrane ruffling
Endosomal maturationCoordinates endosome-lysosome fusion
Neurite extensionSupports axonal growth cone formation
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections19 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
FUS (Redirect)
redirect · KG edge: associated_with
SOD1 (Redirect)
redirect · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

ALS2 associated_with ALSIN
FIG4 associated_with ALSIN
FUS associated_with ALSIN
ALS8 associated_with ALSIN
ALSIN associated_with ALS4
ALSIN associated_with ALS9
ALSIN associated_with TARDBP
ALSIN associated_with ALS7
ALSIN associated_with ALS10
ALSIN associated_with SOD1

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