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gene 1,273 words KG: ALS8
Contents

ALS8 - Amyotrophic Lateral Sclerosis 8

🧬 Gene Info
Gene SymbolALS8
Full NameAmyotrophic Lateral Sclerosis 8
AliasesPage for ALS8
Chromosome20q13.33
Protein TypeType III ER membrane protein
Functionis a genetic locus associated with familial amyotrophic lateral sclerosis (ALS).
Primary ExpressionUbiquitous, high in brain and spinal cord
Amino Acids243 aa
UniProt IDQ9UBS4
Ensembl IDENSG00000124194
OMIM607348
GeneCardsALS8
Human Protein AtlasALS8
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections21 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (26)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withNeurodegeneration
disease · KG edge: implicated_inFUS (Redirect)
redirect · KG edge: associated_withSOD1 (Redirect)
redirect · KG edge: associated_withDNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

ALS2 associated_with ALS8
FIG4 associated_with ALS8
FUS associated_with ALS8
ALS8 associated_with ALSIN
ALS8 associated_with ALS4
ALS8 associated_with ALS9
ALS8 associated_with TARDBP
ALS8 associated_with ALS7
ALS8 associated_with ALS10
ALS8 associated_with SOD1

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