protein

PNN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

17Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for PNN Protein (Pinin)

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🔬 Protein Info

Gene Symbol	PNN
Aliases	Pinin
Function	PNN (Pinin), also known as PNN (Pinin), is a nuclear and desmosome-associated protein involved in RNA splicing and cell adhesion.
Molecular Weight	82 kDa
Amino Acids	717 aa
Pathways	senescence
GeneCards	PNN
Human Protein Atlas	PNN
Associated Diseases	ALS, neuroinflammation
Interactions	ADAMTS-4, CSF1R, MMP2, MMP9, PV
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PNN["PNN"]
    microglia(["microglia"])
    PNN -->|"expressed in"| microglia
    DAM_microglia["DAM microglia"]
    PNN -->|"expressed in"| DAM_microglia
    astrocytes(["astrocytes"])
    PNN -->|"expressed in"| astrocytes
    cholinergic_neurons["cholinergic neurons"]
    PNN -->|"expressed in"| cholinergic_neurons
    neurons(["neurons"])
    PNN -->|"expressed in"| neurons
    senescence["senescence"]
    PNN -->|"participates in"| senescence
    neurodegeneration["neurodegeneration"]
    PNN -->|"cleaves"| neurodegeneration
    Parkinsons_disease["Parkinson's disease"]
    PNN -->|"cleaves"| Parkinsons_disease
    ADAMTS_4["ADAMTS-4"]
    ADAMTS_4 -->|"activates"| PNN
    MMP2["MMP2"]
    MMP2 -->|"cleaves"| PNN
    MMP9["MMP9"]
    MMP9 -->|"cleaves"| PNN
    MMP2 -->|"activates"| PNN
    MMP9 -->|"activates"| PNN
    MMP2 -->|"co expressed with"| PNN
    MMP9 -->|"co expressed with"| PNN
    style PNN fill:#0d47a1,stroke:#42a5f5,stroke-width:2px,color:#fff

Outgoing (17)

Target	Relation	Type	Str
PV	activates	gene	0.80
microglia	expressed_in	cell_type	0.65
ALS	associated_with	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
PV	expressed_in	gene	0.60
PV	inhibits	gene	0.60
neuroinflammation	implicated_in	disease	0.60
oxidative stress response	participates_in	pathway	0.60
PV	translocates_to	gene	0.60
neuroinflammation	activates	disease	0.60
astrocytes	expressed_in	cell_type	0.55
cholinergic neurons	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
senescence	participates_in	pathway	0.55
neurodegeneration	cleaves	disease	0.55
Parkinson's disease	cleaves	disease	0.55
DAM microglia	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
ACC	expressed_in	gene	0.60
CSF1R	activates	gene	0.60
MMP2	cleaves	gene	0.55
MMP9	cleaves	gene	0.55
MMP2	activates	gene	0.55
MMP9	activates	gene	0.55
MMP2	co_expressed_with	gene	0.55
MMP9	co_expressed_with	gene	0.55
ADAMTS-4	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PNN in their description or question text

No additional research found

PNN