protein

ADAMTS-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAMTS-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

3Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for ADAMTS-4 Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	ADAMTS
Function	The catalytic domain coordinates a zinc ion through three histidine residues (H369, H373, H379) and a glutamate (E370) acts as the general base for catalysis.
GeneCards	ADAMTS
Human Protein Atlas	ADAMTS
Interactions	PNN
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

ADAMTS-4 Protein

protein · 992 words

→

Pathway Diagram

graph TD
    ADAMTS_4(["ADAMTS-4"])
    style ADAMTS_4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    PNN(["PNN"])
    microglia["microglia"]
    DAM_microglia(["DAM microglia"])

    ADAMTS_4 -->|"activates"| PNN
    ADAMTS_4 -->|"expressed_in"| microglia
    ADAMTS_4 -->|"expressed_in"| DAM_microglia

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class PNN protein
    class microglia mechanism
    class DAM_microglia protein

Outgoing (3)

Target	Relation	Type	Str
PNN	activates	gene	0.55
microglia	expressed_in	cell_type	0.55
DAM microglia	expressed_in	cell_type	0.55

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ADAMTS-4 in their description or question text

No additional research found