| Gene Symbol | NPY |
| Chromosome | 7p15.1 |
| Function | The NPY gene encodes a prepropeptide that undergoes proteolytic processing to yield the mature NPY peptide. |
| Primary Expression | hippocampus, Hypothalamus, Brainstem, Thalamus, Amygdala |
| Amino Acids | 36 aa |
| Pathways | Er Stress, Mtor, Lipid Metabolism, Autophagy, Akt |
| Ensembl ID | ENSG00000157240 |
| GeneCards | NPY |
| Human Protein Atlas | NPY |
| Y1 Receptor (NPY1R) | Gi/o-coupled, inhibits adenylate cyclase, activates MAPK pathways, increases intracellular calcium |
| Y2 Receptor (NPY2R) | Gi/o-coupled, presynaptic inhibition, regulates neurotransmitter release |
| Y4 Receptor (NPY4R) | Gi/o-coupled, primarily peripheral expression |
| Y5 Receptor (NPY5R) | Gi/o-coupled, involved in food intake and seizure regulation |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis |
| Interactions | ABCA7, ADCY2, AIF1, AKT, Albumin, ALZHEIMER |
| KG Connections | 300 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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