| Gene Symbol | MMP14 |
| Aliases | Matrix Metalloproteinase 14 |
| Function | MMP14 serves multiple physiological functions |
| Molecular Weight | 63 kDa |
| Pathways | Mapk, Apoptosis, Nf-Κb |
| UniProt ID | [P50281](https://www.uniprot.org/uniprot/P50281) |
| NCBI Gene ID | 4323 |
| GeneCards | MMP14 |
| Human Protein Atlas | MMP14 |
| Propeptide domain | Maintains enzyme latency via cysteine switch |
| Catalytic domain | Contains zinc-binding motif (HELGH) |
| Hemopexin-like domain | Mediates substrate recognition |
| Transmembrane domain | Anchors protein to cell membrane |
| Cytoplasmic tail | Regulates intracellular trafficking[@strongin1995] |
| Neuroinflammation | Upregulated in reactive astrocytes around amyloid plaques, contributing to inflammatory milieu.[@wilcock2011] |
| Associated Diseases | neurodegeneration |
| Interactions | AND, APOPTOSIS, INFLAMMATION, MMP9, TNF, TNF-Α |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!