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mechanism 1,528 words KG: lysosome
Contents

Lysosome Dysfunction in Neurodegeneration

⚙ Mechanism Info
Namelysosome
Key Genes/Proteinsalpha-synuclein, BECN1, CTSD, GBA, GBA1, MTORC1
Related Diseasesneuroinflammation
Related Pathwaysreticulophagy
Linked Hypotheses10 hypotheses

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Related Hypotheses (156)

APOE-Dependent Autophagy Restoration
Score: 0.88Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE Isoform Conversion Therapy
Score: 0.72Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60Extracellular Vesicle Biogenesis Modulation
Score: 0.58HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
← Prevpg 8/8

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

lysosome regulates STING1
reticulophagy regulates lysosome
SQSTM1 regulates lysosome
lysosome regulates autophagy
VPS16 participates_in lysosome
alpha-synuclein co_discussed lysosome
lysosome co_discussed neuroinflammation
MTORC1 interacts_with lysosome
Slc45A1 expressed_in lysosome
astrocyte co_discussed lysosome

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