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ai_tool 454 words KG: alpha-synuclein
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GYDE (Collaborative Protein Design Platform)

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Wikipedia

Related Hypotheses (11)

A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes
Score: 0.68Physiological SCFAs may reduce alpha-synuclein burden primar
Score: 0.65m6A-dependent control of alpha-synuclein transcript fate and
Score: 0.63CSF ApoE- and clusterin-rich lipoprotein particles stabilize
Score: 0.61Ganglioside-rich extracellular vesicles preserve alpha-synuc
Score: 0.58Direct neuronal HDAC inhibition is unlikely to mediate thera
Score: 0.56Physiological SCFAs may worsen alpha-synuclein pathology thr
Score: 0.55Glucosylceramide accumulation nucleates alpha-synuclein aggr
Score: 0.53Sulfated glycans and metal-binding CSF proteins brace alpha-
Score: 0.49Propionate may outperform acetate or butyrate at physiologic
Score: 0.44H2S/butyrate imbalance drives enteric alpha-synuclein pathol
Score: 0.38

Knowledge Graph (12 edges)

PINK1 associated_with alpha-synuclein
alpha-synuclein interacts_with mitochondrial dysfunction
SNCA encodes alpha-synuclein
alpha-synuclein associated_with Parkinson's disease
ubiquitin-proteasome system regulates alpha-synuclein
autophagy-lysosome pathway regulates alpha-synuclein
alpha-synuclein inhibits autophagy-lysosome pathway
autophagy-lysosomal pathway activates alpha-synuclein
SNCA produces alpha-synuclein
alpha-synuclein causes dopaminergic neurons

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