Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC45A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SLC45A1 |
| Key Genes/Proteins | V-Atpase |
| Related Diseases | Lysosomal Ph, lysosomal storage disorder, neurodegeneration, Slc45A1-Associated Disease |
| Related Pathways | Lysosomal Dysfunction, mitochondrial function |
graph TD
SLC45A1[SLC45A1]
SLC45A1 -->|causes| lysosomal_storage_disorder[lysosomal storage disorder]
SLC45A1 -->|causes| Slc45A1_Associated_Disease[Slc45A1-Associated Disease]
SLC45A1 -->|regulates| Lysosomal_Dysfunction[Lysosomal Dysfunction]
SLC45A1 -->|expressed in| Neurons[Neurons]
SLC45A1 -->|expressed in| neuron[neuron]
SLC45A1 -->|interacts| V_Atpase[V-Atpase]
SLC45A1 -->|regulates| Lysosomal_Ph[Lysosomal Ph]
SLC45A1 -->|regulates| Iron_Homeostasis[Iron Homeostasis]
SLC45A1 -->|expressed in| lysosome[lysosome]
SLC45A1 -->|implicated in| Neurodegeneration[Neurodegeneration]| Target | Relation | Type | Str |
|---|---|---|---|
| Lysosomal Dysfunction | regulates | mechanism | 0.95 |
| Slc45A1-Associated Disease | causes | disease | 0.95 |
| lysosomal storage disorder | causes | disease | 0.95 |
| Neurons | expressed_in | cell_type | 0.95 |
| V-Atpase | interacts_with | protein | 0.90 |
| neuron | expressed_in | cell_type | 0.90 |
| Lysosomal Ph | regulates | phenotype | 0.90 |
| Iron Homeostasis | regulates | process | 0.90 |
| lysosome | expressed_in | process | 0.90 |
| Neurodegeneration | implicated_in | process | 0.90 |
| neurological disease | biomarker_for | disease | 0.85 |
| sugar transport | involved_in | process | 0.85 |
| V1 subunit stability | modulates | phenotype | 0.85 |
| V-ATPase | interacts_with | protein | 0.80 |
| mitochondrial function | participates_in | pathway | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| neurodegeneration | interacts_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC45A1 in their description or question text
No additional research found