| Gene Symbol | HTRA2 |
| Full Name | HtrA Serine Peptidase 2 |
| Aliases | HtrA2 / Omi |
| Chromosome | 2p13.1 |
| Protein Type | Protease |
| Function | is a nuclear-encoded mitochondrial serine protease that plays critical roles in cellular protein quality control and apoptosis regulation[@ncbi]. |
| Primary Expression | regions vulnerable to neurodegenerative processes[@strauss2005]: |
| Subcellular Localization | Mitochondrial intermembrane space |
| Molecular Weight | 48 kDa |
| Amino Acids | 458 aa |
| Exons | 8 |
| Pathways | Autophagy, Cholesterol, Oxidative Stress |
| UniProt ID | O43464 |
| NCBI Gene ID | 27429 |
| Ensembl ID | ENSG00000103472 |
| OMIM | 606476 |
| GeneCards | HTRA2 |
| Human Protein Atlas | HTRA2 |
| Associated Diseases | Infection, Inflammation, Sepsis |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACOX1, Adiponectin, ADIPOQ, AMPK, APOPTOSIS, ATG |
| KG Connections | 264 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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