| Gene Symbol | GBA1 |
| Full Name | Glucocerebrosidase |
| Chromosome | 1q22 |
| Protein Type | Enzyme |
| Function | is a lysosomal enzyme encoded by the GBA1 gene that plays a critical role in the breakdown of glucocerebroside into glucose and ceramide. |
| Molecular Weight | 52 kDa |
| Amino Acids | 497 aa |
| Exons | 11 |
| Pathways | Akt, Blood-Brain Barrier, Immune Response, Pi3K |
| UniProt ID | P04062 |
| NCBI Gene ID | 2629 |
| Ensembl ID | ENSG00000177693 |
| OMIM | 606463 |
| GeneCards | GBA1 |
| Human Protein Atlas | GBA1 |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, dementia with Lewy bodies |
| Known Drugs/Compounds | AAV5, AAV9, Ambroxol, Bi-Htfr1, BI-hTFR1, levodopa |
| Interactions | ABCA1, Actin, AKT, ALPHA-SYNUCLEIN, AMPK, AND |
| SciDEX Hypotheses | GBA1-Deficiency Disrupts Mitochondrial- Lysosomal PD-Associated GWAS Variants in CTSO and CTSF Genes Glucosylceramide Accumulation from GCase Deficienc (+1 more) |
| KG Connections | 419 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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