gene 1,570 words KG: WDR41
Contents

WDR41 Gene

🧬 Gene Info
Gene SymbolWDR41
Full NameWD Repeat Domain 41
AliasesWDR41 gene encoding WD repeat domain 41
Chromosome9p21.1
Functionencodes a protein containing WD40 repeat domains that mediate protein-protein interactions.
Primary Expressionmost human tissues: - Brain: High expression in neurons - Liver: Metabolic functions - Kidney: Transport functions - Muscle: High ener
Molecular Weight42 kDa
Amino Acids376 aa
PathwaysMtor
UniProt IDQ9H0X4
NCBI Gene ID25828
Ensembl IDENSG00000137265
OMIM614739
GeneCardsWDR41
Human Protein AtlasWDR41
Associated DiseasesAls, FTDALS1
Known Drugs/Compoundsrapamycin
InteractionsALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATG, AUTOPHAGY
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
Autophagosome Maturation Checkpoint Control
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: interacts_with
C9orf72 — Chromosome 9 Open Reading Frame 72
gene · KG edge: interacts_with
fip200
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FIP200 associated_with WDR41
SMCR8 interacts_with WDR41
WDR41 associated_with ULK1
WDR41 interacts_with C9ORF72
FIP200 interacts_with WDR41
WDR41 interacts_with FLCN
PQLC2 binds WDR41
C9orf72 interacts_with WDR41
WDR41 interacts_with SMCR8
WDR41 inhibits cell_viability

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