gene 723 words KG: VAPB
Contents

VAPB (VAMP-Associated Protein B)

🧬 Gene Info
Gene SymbolVAPB
Full NameVesicle-Associated Membrane Protein-Associated Protein B
AliasesVAMP-Associated Protein B
Chromosome20q13.33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight33 kDa
Amino Acids243 aa
PathwaysImmune Response
UniProt IDO95295
NCBI Gene ID9217
Ensembl IDENSG00000124194
OMIM608627
GeneCardsVAPB
Human Protein AtlasVAPB
ER homeostasisMaintains endoplasmic reticulum function and calcium signaling
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Cardiovascular, Dementia, Ms
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, FUS, LYSOSOME, MTORC1
KG Connections83 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Diseases Overview
disease · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Mitochondria
entity · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with

Knowledge Graph (12 edges)

C9ORF72 associated_with VAPB
VAPB associated_with CHMP2B
VAPB associated_with TARDBP
VAPB associated_with SOD1
VAPB associated_with FUS
NPC1 activates VAPB
CGAS regulates VAPB
VAPB regulates TBK1
VAPB regulates STING
OVERVIEW therapeutic_target VAPB

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