gene 561 words KG: UGCG
Contents

UGCG Gene

🧬 Gene Info
Gene SymbolUGCG
AliasesUDP-Glucose Ceramide Glucosyltransferase
FunctionThe UGCG gene encodes UDP-glucose ceramide glucosyltransferase (UGCG), also known as glucosylceramide synthase.
Primary Expressionglial cells including astrocytes and oligodendrocytes
Subcellular Localizationthe Golgi apparatus where it transfers glucose from UDP-glucose to ceramide. Dysregulation of glycosphingolipid metaboli
Molecular Weight46 kDa
PathwaysApoptosis, Nf-Κb, Oxidative Stress, Wnt, apoptosis pathway
Ensembl IDENSG00000165269
GeneCardsUGCG
Human Protein AtlasUGCG
Associated DiseasesAls
InteractionsAPOPTOSIS, CD63, CD9, ERK, OXIDATIVE STRESS, RAB35
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Exosomes
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
CD63
gene · KG edge: activates
CD9
gene · KG edge: activates

Knowledge Graph (12 edges)

UGCG activates STING
CD63 activates UGCG
CD9 activates UGCG
RAB35 activates UGCG
UGCG activates RAB5
OXIDATIVE STRESS activates UGCG
ERK activates UGCG
UGCG activates Heart Failure
UGCG interacts_with Als
UGCG associated_with Sphingolipid

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