gene 2,227 words KG: SYNAPTOPHYSIN
Contents

SYNAPTOPHYSIN Gene

🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesALS, Epilepsy, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ANXIETY, APP
KG Connections309 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (53)

Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
← Prevpg 3/3

Related Analyses (23)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (12)

DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40

See Also (5)

blarcamesine-axon
clinical_trial · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
ATG9A Gene
gene · KG edge: co-localizes
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

SYNAPTOPHYSIN biomarker_for BACE1
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for SYNAPTOPHYSIN
TNF activates SYNAPTOPHYSIN
APP activates SYNAPTOPHYSIN
SYNAPTOPHYSIN activates IL6
SYNAPTOPHYSIN activates BDNF
SYNAPTOPHYSIN activates GFAP
NFL biomarker_for SYNAPTOPHYSIN
ATG9A co-localizes SYNAPTOPHYSIN

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