gene 749 words KG: STAR
Contents

STAR — Steroidogenic Acute Regulatory Protein

🧬 Gene Info
Gene SymbolSTAR
Full NameSteroidogenic Acute Regulatory Protein
AliasesSTART1, STARD1
Chromosome8p11.23
FunctionCholesterol accumulates at mitochondria-ER contact sites
Primary ExpressionBrain (neurons, glia), adrenal gland, gonads
Amino Acids285 aa
PathwaysAngiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt IDP49675
NCBI Gene ID6779
Ensembl IDENSG00000147548
GeneCardsSTAR
Human Protein AtlasSTAR
C-terminal regulatory regionContains phosphorylation sites
Associated DiseasesAging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
InteractionsAKT, ALZHEIMER, APOPTOSIS, App, ASTROCYTE, ASTROCYTES
KG Connections175 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (80)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61
Netrin-1 Gradient Restoration
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
← Prevpg 4/4

Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (14)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

CD8 expressed_in STAR
CD4 expressed_in STAR
GAIN inhibits STAR
PP2A associated_with STAR
STAR expressed_in CD8
STAR associated_with PP2A
STAR inhibits GAIN
CD4 associated_with STAR
CD8 associated_with STAR
BAX expressed_in STAR

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