gene 859 words KG: SORT1
Contents

SORT1 Gene

🧬 Gene Info
Gene SymbolSORT1
Full NameSortilin 1
Chromosome1p13
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe central nervous system:
Subcellular Localizationthe trans-Golgi network
Molecular Weight110 kDa
PathwaysMAPK, PI3K pathway
UniProt IDQ99549
NCBI Gene ID602458
Ensembl IDENSG00000134247
OMIM602458
GeneCardsSORT1
Human Protein AtlasSORT1
Associated DiseasesAlzheimer
InteractionsENDOSOMES, IGF2R, LRP1, NEK7, RAB7A
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: regulates
AMBRA1 Gene
gene · KG edge: regulates
ATP1A1 Gene
gene · KG edge: regulates
NEK7 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ATP1A1 regulates SORT1
RAB11B regulates SORT1
AMBRA1 regulates SORT1
APOE associated_with SORT1
RAB7A interacts_with SORT1
IGF2R interacts_with SORT1
SORT1 interacts_with NEK7
SORT1 associated_with APOE
SORT1 biomarker_for TREM2
SORT1 biomarker_for neuroinflammation

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