| Gene Symbol | SIRT4 |
| Chromosome | 12q24.31<br> |
| Function | SIRT4 is primarily mitochondrial and regulates several key metabolic processes |
| Molecular Weight | 35 kDa |
| Pathways | Oxidative Stress |
| UniProt ID | Q9NWU1 |
| NCBI Gene ID | 23127 |
| Ensembl ID | ENSG00000057394 |
| GeneCards | SIRT4 |
| Human Protein Atlas | SIRT4 |
| ADP-Ribosylation | Catalyzes ADP-ribosylation of target proteins (primary activity) |
| Glutamine Metabolism | Regulates GDH (glutamate dehydrogenase) activity through ADP-ribosylation, inhibiting glutamine-dependent insulin secretion |
| fatty acid oxidation | Influences fatty acid metabolism in mitochondria |
| Mitochondrial DNA Replication | Interacts with TFAM and mitochondrial DNA polymerase |
| Insulin Secretion | Inhibits pancreatic beta-cell insulin secretion in response to amino acids |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Type 2 Diabetes, Cancer |
| Interactions | SIRT3, SIRT6 |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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