gene 1,061 words KG: SCFD1
Contents

SCFD1

🧬 Gene Info
Gene SymbolSCFD1
Chromosome9q34.3
Functionis a member of the Sec1/Munc18 (SM) protein family that plays essential roles in intracellular vesicle trafficking and membrane fusion events throughout the cell.
Primary Expressionboth excitatory glutamatergic and inhibitory GABAergic neurons - Present in astrocytes and oligodendrocytes - High expression
Molecular Weight41 kDa
Amino Acids372 aa
Exons14
Ensembl IDENSG00000084112
GeneCardsSCFD1
Human Protein AtlasSCFD1
SedlinNamed after the Sedlis syndrome (a form of spondylometaphyseal dysplasia)
Sly1Suppressor of ypt1 in yeast
KIAA0822Formerly used identifier
Associated DiseasesMs
InteractionsAGING, AMPK, EXERCISE, JAK2, KDM5D
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Cross-Seeding Prevention Strategy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Neurodegeneration
disease · KG edge: implicated_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: phosphorylates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Microglia in Neurodegeneration
entity · KG edge: binds
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: upregulates

Knowledge Graph (12 edges)

SCFD1 interacts_with JAK2
SCFD1 associated_with AKT
SCFD1 interacts_with KDM5D
SCFD1 associated_with FOXO1
SCFD1 upregulates TREM2
OxPC causes SCFD1
SCFD1 modulates SNARE complex formation
AGING interacts_with SCFD1
SCFD1 associated_with APOPTOSIS
SCFD1 interacts_with EXERCISE

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