gene 664 words KG: PPT1
Contents

PPT1 Gene - Palmitoyl-Protein Thioesterase 1

🧬 Gene Info
Gene SymbolPPT1
AliasesPage for PPT1 Gene, Palmitoyl-Protein Thioesterase 1
Chromosome1p34.2
Protein FamilyPalmitoyl-protein thioesterase family
Protein TypeEnzyme
Function### Enzymatic Activity
Primary Expressionneurons and glia - Cellular Localization: Lysosomal lumen - Developmental Expression: High during fetal development and e
Molecular Weight34 kDa
Amino Acids306 aa
Exons9
UniProt IDP60617
NCBI Gene ID5538
Ensembl IDENSG00000131238
OMIM256730
GeneCardsPPT1
Human Protein AtlasPPT1
Associated Diseasesneurodegeneration
InteractionsAUTOPHAGY, ENDOSOMES, FERROPTOSIS, IFN, SELF-DNA, TNF
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.98
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
TNF (Redirect)
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
TLR9 — Toll-Like Receptor 9
gene · KG edge: regulates

Knowledge Graph (12 edges)

TLR9 regulates PPT1
TNF activates PPT1
CLN1 causes PPT1
STING regulates PPT1
TMEM106B exacerbates PPT1
SELF-DNA inhibits PPT1
ENDOSOMES inhibits PPT1
IFN inhibits PPT1
PPT1 activates Macrophage
PPT1 activates Dendritic Cell

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