gene 2,198 words KG: PLEC
Contents

PLEC Gene

🧬 Gene Info
Gene SymbolPLEC
Full NamePlectin
Chromosome8q24.3
Protein FamilyPlakin family, cytolinker proteins
Functionencodes a protein of approximately 500 kDa, making it one of the largest known proteins.
Primary Expressiondopaminergic neurons - Supports neuronal cytoskeletal integrity - Altered expression in PD
Molecular Weight500 kDa
UniProt IDQ15120
NCBI Gene ID5339
Ensembl IDENSG00000109189
OMIM162284
GeneCardsPLEC
Human Protein AtlasPLEC
Associated DiseasesAls, Alzheimer's Disease
InteractionsALZHEIMER, ASTROCYTES, C1Q, Proteins, RNA
KG Connections64 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Quantum Coherence Disruption in Cellular Communication
Score: 0.63

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (10)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
GFAP (Redirect)
redirect · KG edge: therapeutic_target
Microglia in Neurodegeneration
entity · KG edge: associated_with
Genes
index · KG edge: expressed_in

Knowledge Graph (12 edges)

PLEC expressed_in brain astrocytes
PLEC expressed_in C1Q
GFAP therapeutic_target PLEC
NDUFV1 therapeutic_target PLEC
MAPK14 therapeutic_target PLEC
PLEC therapeutic_target CRYAB
PLEC therapeutic_target CASP3
C1Q expressed_in PLEC
C1Q interacts_with PLEC
C1Q co_mentioned PLEC

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...