| Gene Symbol | NDUFV1 |
| Full Name | NADH:Ubiquinone Oxidoreductase Core Subunit V1 |
| Chromosome | 11q13.2 |
| Protein Type | Oxidoreductase |
| Function | encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase). |
| Primary Expression | brain tissue: |
| UniProt ID | [P22415](https://www.uniprot.org/uniprot/P22415) |
| Ensembl ID | ENSG00000167792 |
| GeneCards | NDUFV1 |
| Human Protein Atlas | NDUFV1 |
| Mitochondrial complex I deficiency | Well-documented in PD substantia nigra |
| Oxidative stress | Increased reactive oxygen species |
| PINK1/PARKIN pathway | Mitophagy defects compound the problem |
| Mitochondrial dysfunction | Early event in AD pathogenesis |
| Energy deficit | Reduced ATP production |
| Associated Diseases | neurodegeneration |
| Interactions | GABRB2, GABRB3 |
| SciDEX Hypotheses | Mitochondrial Dysfunction in Neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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