gene 640 words KG: PDIA6
Contents

PDIA6 - Protein Disulfide Isomerase Family A Member 6

🧬 Gene Info
Gene SymbolPDIA6
Full NameProtein Disulfide Isomerase Family A Member 6
AliasesERP29/P5
Chromosome2p25.1
Protein TypeIsomerase
FunctionPDIA6 functions as a chaperone and assists in protein folding in the endoplasmic reticulum.
Primary Expressionmost tissues with high expression in brain, lung, and pancreas
Molecular Weight48 kDa
PathwaysApoptosis, apoptosis, apoptosis pathway
UniProt ID[Q15020](https://www.uniprot.org/uniprot/Q15020)
Ensembl IDENSG00000143870
GeneCardsPDIA6
Human Protein AtlasPDIA6
PDI (PDIA1)Canonical protein disulfide isomerase and PDIA6 family prototype
GRP78/BiPER chaperone and PDIA6 interaction partner
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, IL1A, Insulin, SLC16A1
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (14)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Insulin Receptor Substrate 1 (IRS-1)
entity · KG edge: activates
Genes
index · KG edge: biomarker_for
DNAJB9 Gene
gene · KG edge: protects_against

Knowledge Graph (12 edges)

PECAM1 protects_against PDIA6
FOS protects_against PDIA6
FGF1 protects_against PDIA6
FGF5 protects_against PDIA6
IL1A interacts_with PDIA6
XBP1 protects_against PDIA6
DNAJB9 protects_against PDIA6
ERN1 protects_against PDIA6
PDIA6 activates SLC16A1
PDIA6 associated_with SLC16A1

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