gene 585 words KG: OXR1
Contents

OXR1 — Oxidoreductase NRD1

🧬 Gene Info
Gene SymbolOXR1
Full NameOxidoreductase NRD1
Chromosome8q23.3.
Protein TypeOxidoreductase
FunctionOXR1 is a conserved protein with oxidoreductase activity.
Primary Expressiondopaminergic neurons and is critical for their survival - oxidative stress: PD brains show increased oxidative markers; OXR1 deficiency exacerbat
Molecular Weight73 kDa
Amino Acids660 aa
Exons17
PathwaysOxidative Stress
UniProt IDQ9C0A1
NCBI Gene ID55074
GeneCardsOXR1
Human Protein AtlasOXR1
Oxidative stress responseOXR1 expression is upregulated in response to oxidative stress
Associated Diseasesneurodegeneration
InteractionsAND, DMSO, HCRT, HCRT1, NEURODEGENERATION, NRF2
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (2)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63

Related Analyses (2)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (18)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Protein Aggregation Kinetic Validation Results
validation · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (6)

Microglia
cell · KG edge: therapeutic_target
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
IL6 (Redirect)
redirect · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: therapeutic_target

Knowledge Graph (12 edges)

OXR1 therapeutic_target IL6
OXR1 activates STAT3
OXR1 therapeutic_target APP
OXR1 activates NRF2
OXR1 inhibits HCRT
OXR1 associated_with HCRT
OXR1 expressed_in HCRT
OXIDATIVE STRESS activates OXR1
OXR1 therapeutic_target AMYLOID
OXR1 therapeutic_target NEUROINFLAMMATION

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